doi: 10.3164/jcbn.14-1
doi: 10.1111/jcpe.13833 72 GiriS.UeharaO.TakadaA.PaudelD.MorikawaT.ArakawaT.et al
Differentiated cells express key hepatocyte markersincluding albumin, tyrosine aminotransferase (TAT), and cytokeratin-18 (CK18)at both the mRNA and protein levels and exhibit essential hepatocyte functions, such as albumin secretion, glycogen storage, and cytochrome P450 7A1 expression, thereby effectively mimicking the metabolic and detoxification functions of mature hepatocytes (Malik et al., 2018)
Several adult-onset cholestasis share mutations in PFIC genes, usually as single heterozygosity, albeit presenting with different phenotypes compared to children-onset PFIC
Meanwhile, targeted metabolomics analysis revealed lower -KG/succinate and -KG/fumarate ratios in shGDH1 cells, two indicators of TET activity (Supplementary Fig
Mol Cell Biol 26:92209231 Page S, Fischer C, Baumgartner B et al (1999) 4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis
